No refrigeration is critical, so store it in a convenient location for you. These probiotics are microorganisms advantageous towards your Doggy’s digestive tract, that means this spray is all-all-natural. These microorganisms do the job by improving the good microbes which have been previously present while in the Doggy’s digestive tract. https://www.amazon.com/Healthy-Treatz-Probiotic-Chews-Dogs/dp/B07VCGNM6X