Bradbury & Kopp [fifty seven] patented the manufacture of two unique extracts from cocoa shells; theobromine fraction and polyphenol enriched fraction. The defatted cocoa shells can be extracted with a solution of acetone/drinking water, and then the acetone needs to be divided, leaving just the aqueous solution. Matsumoto et al. https://gunnergfvma.tribunablog.com/not-known-factual-statements-about-cocoa-shell-47948793