Pentobarbital will decrease the level or effect of budesonide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. pentobarbital will decrease the level or effect of zonisamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. pentobarbital will decrease the level or effect of pantoprazole by affecting hepatic/intestinal en... https://getsocialnetwork.com/story5833637/la-guida-definitiva-a-pentobarbital-half-life